Guidance
A case for change: the challenge to develop a better approach to assessing risk of cancer caused by chemicals
A guidance statement calling for improved, modern methods to assess cancer risk from chemicals, moving beyond binary classifications and animal testing.
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The guidance statement outlines the Committee on Carcinogenicity鈥檚 call to reform how cancer risk from chemicals is assessed, advocating for a more modern, human-relevant, and risk-based approach. It highlights key areas for change, including:
- moving away from outdated binary classifications and animal testing
- embracing new approach methodologies (NAMs) and mechanistic data
- encouraging submissions of case studies using innovative methods
- sharing insights from workshops in agrochemical and cosmetics sectors
- addressing challenges in regulation and public communication
- aiming to enhance public health protection and reduce testing burdens
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Published 11 July 2025
Last updated 11 July 2025
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